Nasolabial folds also known as smile lines or laugh lines are wrinkles in facial skin that run from the corners of the mouth to the bottom of the nose.

Juvederm or Juvéderm is an injectable filler used to soften or remove nasolabial folds. Juvederm was approved by the U.S. Food and Drug Administration in 2006. [^{See a list of FDA Approved Wrinkle Fillers}]. FDA approval is for the safe and effective use as a wrinkle filler when injected into the nasolabial folds. Approval was determined by findings collected from controlled clinical studies.

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